The issue begins with the CEO of Phizzy Cola industries -the parent company of Burger Town, Mirinda Pullman, getting a call from Norah Winters. In Superior Spider-Man 4, Massacre, the villain in this story, massacres everyone in the restaurant, save 2 fortunate lives.
As such, all the reporters want to hear what the owners of Burger Town have to say. Just then, Massacre turns up at Ms Pullman's residence and forces her to hire him to commit more murders while wearing their competitors shirt for $12 million.
Meanwhile, Spider-Man is getting the help of Uatu to help him create a device to track down Massacre. Once the device is complete, Spider-Man changes to Peter and goes for his 'extra classes,' for his doctorate. Peter, really being Dr Octopus, is much smarter than his tutor but continues to stay for class only because his tutor is a very good cook.
After having a hearty meal, Peter Octopus changes to Spider-Man and proceeds to track Massacre. He finds the hostages Massacre has kept hidden in a building some blocks away.
He defuses all the bombs the hostages are tied to, and then goes to find the killer himself.
Meanwhile, a number of blocks away, Massacre has already started shooting. police officers at Grand Central Station. ( Spider-Man told the cops Massacres location as soon as he found out)
Spider-Man manages to sneak into the windows of the building, saves a kid and takes out Massacre. Having witnessed enough murders at Massacre's hand, Spider-Man kills him with a gun.(Obviously against the will of Ghost Spidey aka the real Spider-Man)
Just before Massacre is killed however, he shows some form of emotion - Fear, and actually manages to shed some tears. This does not change a thing for Spider-Ock as he shows the killer no mercy.
Back at Mirinda Pullman's apartment, Mirinda is watching the news, amused that there is not a single mention of Mocha Cola, her competitor, whose shirt was worn by Massacre during the massacre. ( That just sounds weird) Just as she proceeds to turn off the TV, her lights go out, and Spider-Man appears on her TV telling her that he knows she paid Massacre and tells her to tell the authorities what she did, or else, he will deal with her himself!
In this issue, Spider-Man has for teh first time crossed the line and murdered a person in cold blood. No doubt, it is not Peter Parker as Spider-Man, nonetheless, no one knows this, and it will forever go down in history in the minds of New Yorkers.
I imagine that the Avengers, FF, and Mary Jane would probably have a lot to say about this. It is likely that this event is going to be all over the news, especially since Mayor Jameson was extremely supportive of Spider-Man killing Massacre.
By now, close friends like MJ should know that something is up with the new Spider-Man ( I hope)
We also see that Spider-Ock has changed the meaning to " With Great Power comes Great Responsibility" With his new ability to see everything in the city, it looks like Spider-Ock has taken it on himself to be a Batman/Punisher version of Spider-Man.