This piece is going to include spoilers for Ultimate Spider-Man #160 AKA "The Death of Spider-Man" Part 5. Though I suspect it's rather difficult for anyone who is a big enough Spider-Man fan to come to this website to not know what happens in the story.
This is it! This is the shadow every single comic book creator has been chasing for forty years, the long twisted shadow of the greatest comic book villain ever created, (no, not Rob Liefeld) Norman Osborn!
Oh, pipe down with your Joker talk and your Doctor Doom whining, I don't want to hear it! Norman Osborn was the finest villain ever concocted. And my point is extremely well illustrated in a recent issue of Tangled Web where comic book scribe Ron Zimmerman fashioned a scene with all of Spider-Man's villains sitting in a bar trading war stories. The issue ends with Norman Osborn revealing himself and bragging the ultimate Spider-Man villain brag: "I killed the woman he loves." The other villains fall silent. They have nothing to top that.