
Story- continuation from Amazing Spider-Man 644
The issue starts with a conversation between two police officers. They're discussing rumors heard regarding Spidey. To sum it up, rumors have it that the friendly neighborhood Spider-Man has been sighted not looking very friendly.
Just then, a crook come running into the police station asking for help, apparently from Spidey, whose been on a rampage. In the next scene, several other crooks come "rolling" into the police station, quite literally in a ball of spider-webbing.
Chameleon is seen with the baby, video conferencing with Octopus. Dr Ock explains how he need the baby's special blood to possibly give himself a new body. Elsewhere, we see Harry, looking at two cylinders of green goblin serum.

In an unnecessary scene, Carlie, bravely tries to stop Tombstone from getting to Lily by firing a few shots at him. As Tombstone turns around to take care of Carlie, Lily presses the last, of many buttons on the cell phone. Just then, her Menace glider comes flying into the wall and crashes into Tombstone.
When asking about Peter, MJ covers for him letting Carlie know that he called saying he was safe. Spidey apparently took him someplace safe during the event at the coffeeshop. ( Amazing Spider-Man 642)
Coming back to Spidey, every villain who comes in his way gets beaten badly. Slowly, Spidey gets some info that Dr. Ock has been working from the Kravinoff mansion. Naturally, Spidey heads off to the Kravinoff Mansion.

He finds the Chameleon there, who, tells Spider-Man everything that had happened out of fear - including how he pretended to be Harry. Spidey's face changes when he realizes that the baby is still alive. Unfortunately, the Chameleon tells him that the Lizard took the baby before he was able to deliver to Dr. Ock.
Thoughts
This story is starting to look good. Spidey is portrayed like an unstoppable Batman, as mentioned earlier. We have more unnecessary Carlie scenes, possibly to build some foundation for a bigger role she might play in the future. Probably the most mysterious scene in this issue would be Harry, with the Goblin Serum. In Amazing Spider-Man 644, he mentioned that he had a plan. Hopefully, he does not turn bad again.